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Swainsonine

Swainsonine is a potent mannosidase inhibitor.1,2, Immunodulator3,4,5 and Anticancer6,7 agent.

Chemical Structure of Swainsonine
Swainsonine

References

1. J.R. Winkler and H.L Segal J. – Biol. chem. 1984, 259 15369
2. J.E. Tropea et al. J. Biol.Chem. 1988, 263 4309
3. D.A. Granato and J.R. Neeser Mol.Immunol. 1987, 24 849
4. S.L. White et al. Biochem. Biophys. Res. Commun. 1988, 150 615
5. M.J. Humphries et al Cancer Res. 1988, 48 1410
6. Ahmed EL Namir et al Tatrahedron. 2002, 56 8579
7. N. Sano et al Mini Review in Chem. History. 2001, 7 145
8. Title: NATURAL PRODUCTS WITH POTENTIAL PHARMACEUTICAL VALUES (CYCLOPAMIN, SWAINSONINE, ISOCUPRECIC ACID) Type: SPEECH Author(s): GARROSSIAN MASSOUD,GARDNER DALE Name of Seminar: NATIONAL CONGRESS ON MEDICINAL PLANTS Type of Seminar: CONGRESS Sponsor: NATIONAL NETWORK OF RESEARCH AND TECHNOLOGY OF MEDICINAL PLANTS Date: 2013, Volume 2 Abstract: A-CYCLOPAMINE AND CANCER: MISREGULATION OF HH SIGNALING HAS BEEN SHOWN TO CAUSE TUMORS, INCLUDING BASEL- CELL CARCINOMA, MEDULLOBLASTOMA, SMALL-CELL LUNG CANCER, PANCREATIC ADENOCARCINOMA, AND SOME PROSTATIC CANCER, ALSO HH SIGNALING HAS BEEN SHOWN TO BE IMPORTANT IN THE MAINTENANCE OF BREAST, BRAIN AND COLORECTAL CANCER...