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US Patent Data

Cyclopamine tartrate salt and uses thereof

Patent number: 8658664
Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides highly water-soluble analogs of cyclopamine that are potent, hedgehog signaling inhibitors less toxic than cyclopamine. The compounds of the present invention are particularly useful in treating cancers associated with hedgehog signalling.
Type: Grant
Filed: August 9, 2010
Issued: February 25, 2014
Assignee: The Board of Regents of the University of Texas System
Inventors: Jingwu Xie, Massoud Garrossian

Carbohydrate-Cyclopamine Conjugates as Anticancer Agents

Application number: 20110275576
Abstract: Various anticancer compounds are disclosed, including a series of carbohydrate-cyclopamine conjugates. These compounds include pyranose, furanose, and mannitol conjugates, linked through a 1,2,3-triazine ring to the nitrogen of cyclopamine. Methods for preparing these compounds, pharmaceutical compositions containing these compounds, and their use as anticancer agents are also disclosed.
Type: Application
Filed: January 6, 2010
Issued: November 10, 2011
Assignee: Utah State University
Inventors: Cheng-Wei T Chang, Massoud Garrossian

Cyclopamine tartrate salt and uses thereof

Application number: 20110092530
Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides highly water-soluble analogs of cyclopamine that are potent, hedgehog signaling inhibitors less toxic than cyclopamine. The compounds of the present invention are particularly useful in treating cancers associated with hedgehog signalling.
Type: Application
Filed: August 9, 2010
Issued: April 21, 2011
Inventors: Jingwu Xie, Massoud Garrossian