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Cyclopamine Derivatives

N-(2-Butene-4-OL) Cyclopamine

  • Molecular Formula: C31H49NO3
  • Molecular Weight: 483

Chemical Structure of N-(2-Butene-4-OL) Cyclopamine
N-(2-Butene-4-OL) Cyclopamine

N-(4-Butaneol) Cyclopamine

  • Molecular Formula: C31H51NO3
  • Molecular Weight: 485

Chemical Structure of N-(4-Butaneol) Cyclopamine
N-(4-Butaneol) Cyclopamine

N-(3-Propanol) Cyclopamine

  • Molecular Formula: C30H49NO3
  • Molecular Weight: 461

Chemical Structure of N-(3-Propanol) Cyclopamine
N-(3-Propanol) Cyclopamine

N-(6-Hexanol) Cyclopamine

  • Molecular Formula: C33H55NO3
  • Molecular Weight: 513

Chemical Structure of N-(6-Hexanol) Cyclopamine
N-(6-Hexanol) Cyclopamine

N-(4-Amino-2-Butene) Cyclopamine

  • Molecular Formula: C31H50N2O2
  • Molecular Weight: 482

Chemical Structure of N-(4-Amino-2-Butene) Cyclopamine
N-(4-Amino-2-Butene) Cyclopamine

N-(6-Aminohexane) Cyclopamine

  • Molecular Formula: C33H56N2O2
  • Molecular Weight: 512

Chemical Structure of N-(6-Aminohexane) Cyclopamine
N-(6-Aminohexane) Cyclopamine

Solubility

All of the above Cyclopamine Derivatives are partially soluble in Ethanol and DMSO. The Cyclopamine Derivatives are freely soluble in T.H.F., CH2Cl2, and CHCl3

References

There is some information regarding activities of amino derivatives on the following references; however, there is no information of alcohol derivatives.

1. Perron, M, et. al. Development 130, 1565 (2003).
2. Taipale, J. et al. Nature 406, 1005 (2000).
3. Garrossian, M. et al. "Synthesis and Anticancer Activity Studies of Cyclopamine Derivatives." Bioorganic & Medicinal Chemistry Letters 18 (2008): 1359-1363.